相关实验视频
Updated: Jun 4, 2025
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
16.4K
与儿科克罗恩病早期胆结肠切除相关的特征
Jessica L Mueller1, Amy J Kaplan1, Jess L Kaplan2
1Department of Pediatric Surgery, Massachusetts General Hospital, Boston, Massachusetts.
The Journal of surgical research
|January 3, 2025
概括
儿童克罗恩氏病 (CD) 患者需要早期手术通常会出现更严重的症状,并在手术前接受更少的药物. 这表明疾病的进展更为激进,需要更早的干预以获得更好的结果.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 外科胃肠道外科手术
- 炎症性肠道疾病研究研究
背景情况:
- 儿科发病的克罗恩病 (CD) 与成人发病的CD相比,表现出更严重的表型.
- 大约三分之一的儿科CD患者需要手术干预.
- 有限的数据存在患者和疾病特征与早期的手术治疗相关的儿科CD.
研究的目的:
- 为了确定患者和疾病特征与早期的手术管理相关的儿科克罗恩病.
- 了解早期手术干预对治疗模式和疾病过程的影响.
主要方法:
- 在2005年至2021年间接受了大脑结核切除术的儿科CD患者 (<22岁) 的回顾性评估.
- 采用了未经调整的统计分析,包括皮尔森基平方测试,t测试和差异分析.
主要成果:
- 135名儿科CD患者接受了胆管切除术,手术的中位时间为3.75年.
- 接受早期手术 (<3.75岁) 的患者在诊断时年龄较大,但在手术时年轻,接受CD药物较少,并且对多种生物药物的暴露较少.
- 腹形成是早期手术更常见的征兆,而晚期手术更常见的是无法生长/耐火性疼痛.
结论:
- 手术治疗是儿科CD管理的一个关键方面.
- 儿科CD早期的手术管理与早期的生物使用有关,生物启动和手术之间的间隔较短,整体药物较少.
- 这些发现表明,早期的手术可能表明儿科克罗恩病的更严重,耐火性疾病表型.
相关概念视频
01:21Inflammatory Bowel Disease V: Surgical Management
116
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
116
01:30Inflammatory Bowel Disease II: Crohn's Disease
183
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
183
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
135
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
135
01:17Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
01:23Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K