Janus LAAM装载的电纤维口膜用于治疗阿片类药物使用障碍
Hadi Sudarjat1, Chaolong Qin1, Diane Ingabire2
1Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Biomaterials
|January 3, 2025
概括
一种新的口膜配方Levo-alpha-acetylmethadol (LAAM) 为治疗阿片类药物使用障碍 (OUD) 提供了更好的生物可用性和疗效. 这种创新的输送方法在减少芬太尼偏好和戒断症状方面显示出希望,有助于打击阿片类药物危机.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 公共卫生 公共卫生
- 材料科学 材料科学 材料科学
背景情况:
- 阿片类药物危机仍然是一个关键的公共卫生问题,自1999年以来,在美国失去了近100万人的生命.
- 目前的阿片类药物使用障碍 (OUD) 治疗面临的挑战是患者的遵从性和由于日常诊所访问而导致的高医疗费用.
- 长期作用的OUD药物Levo-alpha-acetylmethadol (LAAM) 之前已被撤销,但它有可能通过更少的剂量改善患者的坚持.
研究的目的:
- 开发和评估一种新的 Janus LAAM 加载纤维口膜 (LFBF),以改善 OUD 治疗.
- 通过LFBF评估LAAM的跨粘膜传递和生物可用性,与口服溶液相比.
- 在临床前模型中研究LFBF在减少寻找药物的行为和戒断症状方面的有效性.
主要方法:
- 使用电纤维制造一个用Janus LAAM装载的纤维膜 (LFBF).
- 在子中进行的药理动力学研究,以比较LFBF和常规口服LAAM溶液之间的LAAM生物可用性.
- 在 fentanyl 依赖的老鼠模型中进行行为研究,以评估 LFBF 对 fentanyl 选择和戒断症状的影响.
主要成果:
- 与子的口服溶液相比,口服LFBF的使用导致LAAM生物利用率提高了近4倍.
- 在依赖芬太尼的老鼠中,LFBF显著减少了芬太尼的选择,这种效应在相同剂量的口服LAAM溶液中没有观察到.
- 无论是LFBF还是口服LAAM,都减少了实验动物的体质戒断症状,表明了治疗潜力.
结论:
- 电纤维口膜代表了增强LAAM输送的有希望的策略,显著提高了药物的生物可用性.
- 在临床前模型中,LFBF在减少寻找药物的行为方面表现出卓越的有效性,这表明有可能改善OUD治疗结果.
- 这种新的口腔输送系统为LAAM的重新引入提供了潜在的途径,有助于改善阿片类药物危机的治疗选择.
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