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个体结构共变连接体揭示了与童年虐待相关的异常大脑发育轨迹

Yajing Pang¹, Shanshan Zhao¹, Zhiyuan Zhang¹

¹Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, School of Electrical and Information Engineering, Zhengzhou University, Zhengzhou, 450001, China.

Journal of psychiatric research

|January 3, 2025

概括

童年虐待 (CM) 改变了大脑的发育,在年轻人中加速了大脑的发育,但在以后却将其推迟了. 滥用和忽视对神经发育有着不同的影响,在成年阶段对大脑的年龄有不同的影响.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
心理健康研究心理健康研究

背景情况:

儿童虐待 (CM) 与长期的身体和心理健康问题有关,可能是通过神经发育的改变.
对于CM的精确神经生物学影响仍然不完全理解.

研究的目的:

通过使用结构性核磁共振 (MRI) 来调查童年虐待和大脑年龄之间的关系.
为了确定CM如何影响不同成年年龄组的大脑发育轨迹.

主要方法:

分析了来自214名成年人的结构性MRI数据,分为CM和非CM组.
通过结构共变网络和相关性向量回归,估计了大脑连接组年龄.
大脑预测年龄差异 (brain_PAD) 被计算出来,以量化大脑预期年龄的偏差.

主要成果:

在非CM个体中,大脑年龄准确地反映了时间学年龄,但在CM个体中没有.
患有CM的年轻人表现出加速的大脑衰老 (上大脑_PAD),而老年人表现出衰老 (下大脑_PAD).
与忽视不同的是,虐待儿童与较高的脑_PAD有关,而脑_PAD与CM组的注意力冲动性相关.

结论:

童年虐待在成年生活各个阶段对大脑发育产生不同影响.
虐待和忽视儿童对神经发育有着不同的影响模式.
这些发现为CM的结构性大脑发育后果提供了新的见解.

关键词:

大脑预测年龄差异.童年虐待童年虐待冲动性是一种冲动性.结构共变网络的结构共变网络.

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