肝纤维化和心血管事件
Nso Nso1, Kaveh Rezaei Bookani1, Mia Trimingham2
1From the Department of Medicine, Division of Cardiovascular Disease, University of Chicago-Northshore Program, Evanston, Illinois.
通过非侵入性评分 (如FIB-4和NFS) 确定肝纤维化,可以独立预测NAFLD患者的心血管事件和死亡率. 这些简单的分数有助于评估心血管疾病的风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 肝纤维化是非酒精性脂肪性肝病 (NAFLD) 的常见并发症.
- 非侵入性肝纤维化得分 (LFSs) 评估纤维化严重程度.
- 对于未来心血管事件 (CVEs) 的LFS的预测价值尚未得到充分确立.
研究的目的:
- 系统地审查肝纤维化和CVE之间的关联.
- 评估LFS的实用性,特别是纤维化-4 (FIB-4) 指数和NAFLD纤维化得分 (NFS),用于预测CVEs.
主要方法:
- 来自PubMed,Scopus,Web of Science和Cochrane图书馆的前性研究的系统审查.
- 使用国家卫生研究院工具进行资格选和质量评估.
- 包括12个高到相当质量的研究.
主要成果:
- 在12项研究中,10项发现LFS独立与心血管疾病,心血管死亡率和全因死亡率的风险增加有关.
- 晚期肝纤维化 (3-4级) 与CVE发生相关.
- 无论纤维化程度如何,NAFLD患者的CVE风险都更高.
结论:
- 在NAFLD患者中的肝纤维化是不良心血管结果和死亡率的独立预测因素.
- 非侵入性LFS (FIB-4,NFS) 是预测不同患者群体中CVE的有价值工具.
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