慢性呼吸道疾病与中国老年人的虚弱之间的关联:基于人口的纵向研究
Dan Guo1,2, Ke Huang3,4, Xiaolong Guan5
1Aerospace Science and Industry Corporation 731 Hospital, Beijing, China.
BMJ open respiratory research
|January 3, 2025
概括
慢性呼吸道疾病 (CRD) 在老年人中显著增加虚弱风险,特别是喘和喘-COPD重叠. 常规查和CRD的积极管理对于预防脆弱性至关重要.
科学领域:
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性呼吸道疾病 (CRD) 越来越多地被认为是老年人虚弱的潜在危险因素.
- 关于CRD与脆弱性之间的关联的现有证据缺乏最终的共识.
- 这项研究解决了对老年人群中CRD和脆弱性的可靠数据的需求.
研究的目的:
- 调查慢性呼吸道疾病 (CRD) 与中国老年人群的虚弱发展之间的关联.
- 识别特定的CRD,这些CRD具有较高的脆弱风险.
- 为有针对性的查和管理策略提供证据.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) 的数据分析,包括3309名参与者.
- 从2011年开始,在三个波段的纵向随访中,使用物理脆弱现象型尺度评估脆弱性.
- 考克斯的比例危险模型被用来确定基线CRD和事件脆弱性之间的关联.
主要成果:
- 与没有CRD的参与者相比,CRD的参与者表现出明显更高的脆弱性发病率 (每1000人年37.17),而没有CRD的参与者则表现出明显更高的脆弱性发病率 (每1000人年18.41).
- CRD与44%的脆弱性发展风险增加有关 (HR = 1.44).
- 单独的喘 (HR=1.89) 和喘-COPD重叠 (ACO) (HR=1.79) 与较高的脆弱风险有显著的联系,而单独的COPD则没有 (HR=1.11).
结论:
- 在CRD,特别是喘和ACO,与老年人脆弱风险增加之间存在显著的关联.
- 建议在临床和社区环境中进行常规的脆弱性查和CRD的积极管理.
- 预防CRD患者的虚弱进展需要对其呼吸系统状况进行勤奋的控制.
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