肺移植患者的粘菌球菌感染:在西班牙安达卢西亚的经验
Alba María Fernández González1, Ninoska Moreira Lorenzo2, Benito Cantador Huertos3
1Department of Thoracic Surgery, University Hospital Puerta del Mar, Cádiz, Spain; Instituto Maimónides de Investigación Biomédica de Córdoba, IMIBIC, University of Córdoba, Córdoba, Spain; Group for the Study of Thoracic Neoplasms and Lung Transplantation, IMIBIC (Instituto Maimónides de Investigación Biomédica de Córdoba), University of Córdoba, Córdoba, Spain.
Transplantation proceedings
|January 3, 2025
概括
肺移植 (LT) 后的粘菌菌菌感染很少见,但致命,在本研究中死亡率为100%. 早期诊断Mucorales对于改善肺移植接受者的结果至关重要.
科学领域:
- 医学真菌学 医学真菌学
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 粘膜菌感染是肺移植 (LT) 接受者的新兴威胁.
- 这些感染虽然很少见,但在移植肺部中越来越多地被发现.
研究的目的:
- 报告发生在肺移植后的手术后期发生的粘膜菌感染的经验.
- 要突出与这些感染相关的高死亡率.
主要方法:
- 从2000年到2023年在安达卢西亚进行的767次肺移植的回顾性审查.
- 通过微生物学和组织学分析识别粘菌.
主要成果:
- 在LT后的Mucorales感染的发生率不到1%,但死亡率为100%.
- 所有受影响的患者都接受了慢性阻塞性肺病的LT治疗,并发展出扩散性感染.
- 确定的关键风险因素包括皮质类固醇使用,营养不良,先前的固体器官移植,单一的LT,免疫抑制和并发的阿斯伯吉路斯感染.
结论:
- 粘性菌根症是肺移植移植移植中记录不良,致命的并发症.
- 对于肺移植患者的及时诊断和管理,提高对粘原体的警至关重要.
相关概念视频
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...