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Updated: May 7, 2025

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
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对LGR4-RSPO2-ZNRF3复合体的结构洞察,这些复合体调节WNT/β-catenin信号传输

Lu Wang1, Fangzheng Hu1, Qianqian Cui1

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Nature communications
|January 3, 2025
PubMed
概括

LGR4蛋白质含量决定了ZNRF3的组合和构成,调节了WNT/β-catenin信号传递. 这种结构性理解对于开发针对Wnt驱动癌症的药物至关重要.

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