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Updated: Jun 4, 2025

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人类VANGL-PRICKLE相互作用的结构基础

Yanyi Song1, Shuyi Jian2, Junlin Teng2

  • 1State Key Laboratory of Membrane Biology, Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Nature communications
|January 3, 2025
PubMed
概括

这项研究揭示了高样 (VANGL) - - 皮克尔 (PK) 相互作用的结构基础,这对于平面细胞极性 (PCP) 至关重要. 研究人员发现了PK1如何将含有VANGL的囊泡引导到细胞膜,从而推进了对PCP通路的理解.

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