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相关概念视频

The Significance of Membrane Transport01:44

The Significance of Membrane Transport

22.8K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
22.8K
Primary Active Transport01:29

Primary Active Transport

9.7K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
9.7K
Membrane Fluidity01:23

Membrane Fluidity

151.0K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
151.0K
Membrane Transporters01:31

Membrane Transporters

10.3K
Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
10.3K
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

350
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
350
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

276
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
276

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相关实验视频

Updated: Jun 4, 2025

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
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一个非性宏循环的膜透性数据库.

Qiushi Feng1, Danjo De Chavez1, Jan Kihlberg2

  • 1Department of Chemistry-BMC, Uppsala University, SE-75123, Uppsala, Sweden.

Scientific data
|January 3, 2025
PubMed
概括

开发新药对困难的目标来说是具有挑战性的. 这项研究引入了一个数据库和一个新的指标来预测宏循环膜透性,帮助药物发现.

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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

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相关实验视频

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Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
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科学领域:

  • 药用化学 医学化学
  • 计算化学计算化学
  • 药物发现 药物发现 药物发现

背景情况:

  • 药物开发是昂贵的,特别是对于难以获得的药物目标.
  • 宏观循环对调节具有挑战性的目标和口服管理具有前景.
  • 评估膜透性用于药物开发是艰苦而昂贵的.

研究的目的:

  • 创建一个全面的在线数据库的宏循环膜透性数据.
  • 引入一种新的描述符,即胺比率 (AR),用于分类宏循环.
  • 为了在药物发现中促进膜透性的in silico预测.

主要方法:

  • 从文献,专利和存储库中对4216个非性宏循环进行了精选,共计5638个膜透度数据点.
  • 开发了胺比率 (AR) 描述符,以量化宏循环的性质.
  • 建立了一个在线数据库 (https://swemacrocycledb.com/) 提供可访问的数据和预测.

主要成果:

  • 该数据库提供了对非基和半基宏循环的广泛的膜透性数据.
  • 胺比率有效地将宏循环分为性,半性和非性类别.
  • 使用数据库和AR进行in silico预测可以加速药物发现.

结论:

  • 开发的数据库和AR描述符解决了宏循环药物发现资源的关键缺口.
  • 这种资源使膜透率的成本有效预测成为可能,这对于口服生物可用性和细胞内向性至关重要.
  • 为难以获得的药物目标设计和选择宏循环药物候选剂提供便利.