通过体外和体内研究来对抗COVID-19及其Aspergillus tamarii SP73-EGY的共感染
Eman Abdelsalam1, Amal Mosad Ibrahim1, Ahmed A El-Rashedy1
1Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St, Dokki-Giza, Egypt.
Scientific reports
|January 3, 2025
概括
一种Aspergillus tamarii提取物表现出对SARS-CoV-2的强有力的抗病毒特性,其性能优于remdesivir. 这种天然化合物显示出对抗冠状病毒感染和相关并发症的前景.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 自然产品化学 自然产品化学
背景情况:
- 由SARS-CoV-2引起的COVID-19大流行导致了全球显著的死亡率和发病率.
- 与其他微生物的同时感染可以加剧SARS-CoV-2引起的免疫恶化和呼吸道损伤.
研究的目的:
- 评估Aspergillus tamarii SP73-EGY分离提取物对各种病毒的抗病毒疗效,包括SARS-CoV-2.
- 为了研究提取物的潜在抗菌活性,并确定关键的抗病毒成分.
主要方法:
- 对低致病性冠状病毒 (229E),Adeno-7,疹-2和SARS-CoV-2病毒进行了抗病毒测试.
- 评估了对大肠杆菌和P. aeruginosa的抗菌活性.
- 用分子对接和动力学模拟来分析关键化合物与SARS-CoV-2 Mpro. 的结合亲和力.
主要成果:
- 提取物对229E (IC50 = 8.205μg/ml,SI = 43.4) 具有显著的抗病毒活性,对SARS-CoV-2 (IC50 = 8.306μg/ml,SI = 42.2) 具有强烈的疗效,超过了remdesivir.
- 作为主要成分的酸显示出对SARS-CoV-2和remdesivir的抗病毒活性.
- 这种提取物对大肠杆菌和P. aeruginosa具有显著的抗菌功效.
结论:
- 阿斯伯吉illus tamarii 提取物具有显著的抗病毒特性,特别是对抗冠状病毒.
- 酸和其他已识别的化合物显示出潜在的新型治疗药物对抗SARS-CoV-2.
- 提取物具有广泛的活性,因此需要进一步研究,以控制病毒和细菌共感染.
相关概念视频
01:16In-vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
01:16In vitro Mutagenesis
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.