对超过145,000个症状日志的聚类揭示了明显的更年期前,更年期前和更年期前的表型
Shravan G Aras1,2, Azure D Grant3, John P Konhilas4,5
1Center for Biomedical Informatics and Biostatistics, University of Arizona Health Sciences, Tucson, AZ, 85750, USA.
Scientific reports
|January 3, 2025
概括
更年期过渡涉及症状的转变,更年期前妇女经历月经问题,更年期妇女报告血管运动症状. 疲劳,头痛,焦虑和脑雾在所有阶段都很常见,需要更广泛的治疗方法.
科学领域:
- 生殖内分泌学和妇女健康研究.
- 在更年期过渡期间分析症状集群.
背景情况:
- 更年期过渡的特点是月经周期症状的消失和血管运动症状的出现.
- 关于症状出现,聚类和在更年期前,更年期前和更年期期间不同的表型的理解有限.
研究的目的:
- 用MenoLife应用程序的数据分析更年期前,更年期前和更年期妇女的症状模式和集群.
- 在更年期过渡的不同生命阶段识别不同的症状概况和常见的投诉.
主要方法:
- 来自MenoLife应用程序的4789个人和147,501个症状日志的分析.
- 利用等级集群分析 (HCA),K-Means集群和二项式网络分析来识别症状集群.
- 根据月经周期的规律性和更年期的类型 (自然与医学诱导) 评估参与者.
主要成果:
- 绝经前妇女主要报告了与月经周期相关的,消化,情绪和全身症状.
- 更年期妇女主要经历了血管运动,疼痛,情绪和认知症状.
- 绝经前妇女表现出月经和血管运动症状的混合体. 疲劳,头痛,焦虑和脑雾在所有阶段都很普遍. 热除了夜间出汗之外,其预测能力有限.
结论:
- 症状呈现在更年期过渡期间有显著的变化,在更年期前,更年期前和更年期阶段都有不同的特征.
- 诸如疲劳,头痛,焦虑和脑雾等常见症状,在所有生命阶段都构成重大负担.
- 目前的治疗侧重于血管运动症状或月经前综合征,忽视了更广泛的症状负担,强调了针对情绪,认知,消化和整体健康的干预措施的必要性.
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