日本的酒精消费与2型糖尿病风险之间的关联:一项基于人口的纵向队列研究
Yuan-Zhe Huang1, Fang Luo2, Xiong Ran1
1Department of Radiology, Chongqing General Hospital, Chongqing University, Yubei District, Chongqing, 401147, China.
Scientific reports
|January 3, 2025
概括
过度饮酒会增加日本男性的2型糖尿病风险,这些男性的禁食血葡萄糖 (FPG) 含量较高. 然而,在女性或具有正常FPG水平的个人中没有观察到这种关联.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 过度饮酒是2型糖尿病 (T2D) 的已知危险因素.
- 饮酒量,空腹血葡萄糖 (FPG) 水平和T2D风险之间的相互作用尚未完全理解,特别是在特定的人口群体内.
- 了解这些相互作用对于有针对性的公共卫生干预和临床指导至关重要.
研究的目的:
- 研究酒精消费模式与患T2D的风险之间的关系.
- 检查基线FPG水平是否能缓和日本人口中酒精摄入量与T2D发病率之间的关联.
- 根据酒精消费和FPG状态来确定T2D风险较高的特定子组.
主要方法:
- 在5.4年的随访期内,分析了来自日本NAGALA队列的15453名参与者的数据.
- 对酒精消费和FPG水平的基线评估,将参与者分为高FPG (EFPG) 和正常FPG (NFPG) 组.
- 应用Cox比例危险回归模型,按FPG水平分层,以评估与不同酒精摄入量相关的T2D风险.
主要成果:
- 严重的酒精消费与EFPG患者中T2D风险增加88%显著相关 (危险比率[HR]1.88,95%信心区间[CI]1.24-2.84).
- 在NFPG组中没有观察到大量饮酒与T2D风险之间的显著关联 (HR 1.10,95%CI 0.48-2.53).
- 具体而言,患有EFPG和大量饮酒的日本男性显示T2D风险显著增加 (HR 1.83,95%CI 1.08-3.08),进一步得到了倾向性得分匹配的支持.
结论:
- 过度饮酒会给T2D带来很大的风险,特别是在FPG水平升高的日本男性中.
- 与大量酒精摄入相关的T2D风险在女性或正常FPG的个人中没有升高.
- 建议进行进一步的研究来验证这些发现,并探索性别特异性机制和预防策略.
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