在一般人群中阻塞性睡眠呼吸暂停和高尿血/痛风之间的关联:一个横截面研究
Suyeon Park1,2,3, Seong-Hyeok Bak4, Hyun-Sook Kim4
1Department of Biostatistics, Academic Research Office, Soonchunhyang University Seoul Hospital, Seoul, South Korea.
BMC musculoskeletal disorders
|January 3, 2025
概括
高阻塞性睡眠呼吸暂停 (OSA) 风险与高尿路血症有关,但不是严重的病例或痛风. 早期的OSA查可能有助于预防尿酸水平升高.
科学领域:
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与心血管和代谢条件有关.
- 有限的大规模研究探讨了OSA,高尿血和痛风之间的联系.
- 这项研究使用韩国卫生调查数据调查了这种关联.
研究的目的:
- 为了检查阻塞性睡眠呼吸暂停 (OSA) 风险和高尿血/痛风之间的关系.
- 通过使用韩国国家健康和营养调查 (KNHANES) 的数据来评估该协会.
主要方法:
- 利用了来自11,728名参与者的2019-2021年KNHANES数据.
- 通过STOP-BANG问卷评估OSA风险 (低风险,中等风险,高风险).
- 使用多重回归分析了人类学,社会经济,健康和血清尿酸 (SUA) 数据.
主要成果:
- 高OSA风险 (12.2%) 显示显著更高的SUA水平和痛风发病率.
- STOP-BANG得分与SUA水平呈正相关性 (r=0.383,P<0.001).这些得分与SUA水平呈正相关性 (r=0.383,P<0.001).
- 高OSA风险独立与高尿路血症相关 (aOR=1.462),但在调整后没有严重的高尿路血症或痛风.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 的高风险独立地与高尿血症有关.
- 经过对混因素进行调整后,与严重的高尿血和痛风的相关性并不显著.
- 查和管理OSA可能有助于预防高尿血.
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