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重金属暴露和血管年龄之间的关联:一项大型横截面研究

Yuntao Feng^1,2, Chengxing Liu¹, Litang Huang³

¹Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.

Journal of translational medicine

|January 3, 2025

概括

暴露于重金属,包括和,与血管年龄的增加有关. 男人似乎更容易受到金属的联合暴露,这突显了对性别特异性心血管风险评估的需要.

科学领域:

环境健康环境健康
心血管疾病研究研究
毒理学毒理学毒理学

背景情况:

暴露于重金属是心血管疾病 (CVD) 的新兴环境风险因素.
它对血管衰老的影响以及与血管年龄的确切关系需要进一步阐明.

研究的目的:

调查暴露于九种重金属和血管衰老之间的关联.
为了探索重金属相关的血管衰老的性别特异.

主要方法:

从国家健康和营养检查调查 (NHANES) (2005-2016) 中对3772名参与者的横截面分析.
测量尿液中的重金属和评估血管年龄,估计脉冲波速度 (ePWV) 和心血管年龄 (HVA).
应用性别分层分析,加权量子总和 (WQS) 回归和贝叶斯核机器回归.

主要成果:

在 (Cd), (Cs), (Co) 和 (Pb) 暴露和血管年龄增加之间发现了显著的关联 (ORs 1.05-3.48).
(Co) 和 (Cd) 对男性的血管年龄产生了更大的影响.
综合重金属暴露在男性中与血管年龄的增加有较强的关联 (HVA的OR=3.89).

结论:

暴露于重金属与血管年龄的增加显著相关.
男人可能更容易受到多次重金属暴露的综合影响.
调查结果强调了性因素在心血管风险评估和环境暴露管理策略中的重要性.

关键词:

估计的脉冲波速度估计的脉冲波速度.暴露于重金属的情况.血管年龄血管年龄血管衰老血管衰老

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