系统审查甲状腺疾病与甲状腺功能过高的相关性
Adeel Ahmad Khan1, Rohit Sharma2, Fateen Ata3
1Department of Internal Medicine, Cleveland Clinic Akron General, Akron, OH, USA.
Thyroid research
|January 3, 2025
概括
甲状腺疾病,特别是甲状腺功能低下症,通常会导致高甲状腺素的升高. 在大多数患者中,治疗甲状腺激素缺乏症有效地解决了高血和垂体扩大.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
背景情况:
- 甲状腺疾病 (TD),特别是甲状腺功能低下症,是导致高甲状腺蛋白血症 (HPRL) 的重要原因之一.
- 本系统性审查侧重于患有这种临床关联的成年人.
研究的目的:
- 系统地审查成年人的临床特征,管理和治疗结果,这些成年人的HPRL是甲状腺疾病的次要原因.
- 评估甲状腺激素替代治疗对HPRL和脑垂体扩大的影响.
主要方法:
- 在PUBMED,SCOPUS和EMBASE的系统文献搜索到2022年12月15日.
- 包括47篇文章,包括804名HPRL和甲状腺疾病的患者.
主要成果:
- 大多数患者 (85.9%) 是女性;月经不规则是最常见的症状 (74.3%).
- 亚临床甲状腺功能低下是最常见的TD (57.1%).
- 甲状腺激素替代导致HPRL在88.9%的患者中完全消失或改善,而在94.1%的患者中导致下垂体扩大.
结论:
- 在大多数情况下,甲状腺激素替代疗法有效地解决HPRL和相关的脑垂体扩大.
- 在低甲状腺症引起的HPRL中,多巴胺激动剂治疗通常是不必要的.
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