头发中异化的水平预测了结核病液培养转化
概括
伊索尼亚齐德的头发药物水平可以预测结核病患者的唾液培养转化. 平均水平≥0.05 ng/ml表明成功治疗8周.
科学领域:
- 药理动力学和结核病治疗监测监测
背景情况:
- 唾液培养是诊断结核病 (TB) 和评估治疗成功的标准.
- 目前的唾液培养方法有6-8周的周转时间,延迟了关键患者管理决策.
研究的目的:
- 为了确定异化的头发药物水平是否可以预测结核病治疗8周后的唾液培养转化.
主要方法:
- 56名结核病患者被招募并开始接受治疗.
- 唾液和头发样本在基线和第4,8周和第26周收集.
- 使用固体和液体介质进行唾液培养;通过液体染色学-并联质谱法量化头发药物水平.
主要成果:
- 28名参与者完成了这项研究;24名 (86%) 获得了唾液培养负性.
- 阴性唾液培养的患者的头发中位数异化水平为0.0514 ng/ml (IQR为0.1165-0.0314).
- 四名患者 (14.1%) 保持培养阳性,头发中位数异化水平为0.0192 ng/ml (IQR为0.0267-0.0132).
结论:
- 在结核病治疗的强化阶段结束时,异化的毛发度中位数≥0.05 ng/ml可能表明唾液培养转化.
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