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在炎症酶激活交叉路口的MAP激酶信号

Alex Vervaeke¹, Mohamed Lamkanfi¹

¹Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.

Immunological reviews

|January 4, 2025

概括

线素激活蛋白激酶 (MAPK) 信号密切调节炎症体,主要的免疫传感器. 本综述详细介绍了MAPK通路如何控制NLRP3和NLRP1炎症酶激活和细菌毒素操纵.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
细胞信号传递细胞信号传递

背景情况:

炎症酶对宿主防御和炎症至关重要,需要精确的调节.
线素激活蛋白激酶 (MAPK) 信号通路越来越多地被认为是炎症体功能的关键调节者.

研究的目的:

审查MAPK信号传导在调节炎酶激活中的多面性作用.
要突出了解NLRP3和NLRP1炎症酶的MAPK介导调节的最新进展.
讨论MAPK-inflammasome交叉通话的微生物操纵.

主要方法:

关于MAPK信号和炎症酶激活的最新研究的文献综述.
专注于特定的MAPK通路 (ERK1,JNK,TAK1,ZAKα) 和它们的目标 (AP-1,NLRP3,NLRP1).
对涉及Bacillus anthracis致命毒素 (LeTx) 的宿主-病原体相互作用的分析.

主要成果:

包括AP-1,ERK1,JNK和TAK1在内的MAPK通路对于NLRP3炎症细胞原始化,许可和激活至关重要.
MAP3K激酶ZAKα将核糖体压力与人类NLRP1炎症酶激活联系起来.
炭杆菌致命毒素利用MAPK信号诱导巨细胞亡,这种机制被动物Nlrp1b炎症酶激活所抵消.

结论:

MAPK信号传递是整合多种刺激和调节炎酶激活的中心枢纽.
了解MAPK-炎症酶相互作用,可以了解炎症性疾病和宿主-病原体防御.
准MAPK通路可能为炎症疾病和传染病提供治疗策略.

关键词:

在JNK中,JNK就是JNK.这就是MAP激酶.这就是TAK1的意义.一些炎症一些炎症这是一种炎症炎症炎症炎症.在p38中,p38是什么?热致灭 (pyroptosis) 是一种致的过程.

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