牙周炎微生物组与唾液和血清炎症负担相关
Abdulaziz Bakhsh1, Susan Joseph2, Francesco Mannocci3
1Department of Restorative Dentistry, Division of Endodontics, Faculty of Dental Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
International endodontic journal
|January 4, 2025
概括
牙周炎 (AP) 涉及根管微生物群和宿主免疫反应之间的复杂相互作用. 这项研究发现口腔和血液微生物组与炎症标志物之间的相关性,表明AP可能构成系统性炎症风险.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 牙科 牙科是指牙科的专业.
背景情况:
- 牙周炎 (AP) 与复杂的宿主微生物群相互作用有关.
- AP可能会导致局部和全身炎症.
- 关于AP微生物组与炎症标志物之间的相关性的证据有限.
研究的目的:
- 为了识别AP患者的唾液,内和血液样本中的微生物群.
- 研究微生物组 (管内,血液,唾液) 和炎症生物标志物 (血清,唾液) 之间的相关性.
主要方法:
- 唾液,内和血液样本的16S rRNA基因测序.
- 使用多重试验测量血清和唾液炎症标记物的测量.
- 使用斯皮尔曼系数进行相关性分析.
主要成果:
- 在唾液,内和血液样本中观察到明显的微生物概况.
- 在所有样本类型中发现了像Streptococcus和Prevotella这样的常见属.
- 在特定的唾液和内属和唾液炎症标志物 (IL-8,MMP-2,TNF-α,IL-6) 之间发现了显著的相关性.
- 此外,还确定了内类和血清FGF-23之间的相关性,以及血液类和血清炎症标志物 (FGF-23,MMP-9,CRP,IL-8,ICAM-1) 之间的相关性.
结论:
- 唾液,血液和内样本中的微生物群与炎症生物标志物水平相关.
- AP的影响超出了周周区域,可能表明系统性炎症负担.
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