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Updated: Jun 4, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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在循环素依赖的基因酶4,6和9中阐明结合选择性:开发高强度和选择性的CDK4/9抑制剂

Chenran Jiang1,2, Yuxin Ye2, Wei Kang2

  • 1Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of medicinal chemistry
|January 4, 2025
PubMed
概括

开发选择性环素依赖激酶 (CDK) 抑制剂,特别针对CDK4而不是CDK6,可以克服乳腺癌治疗中的耐药性和毒性. 这项研究确定了设计新型CDK4选择性化合物的关键结构差异.

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