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外基因组和非编码RNA:弥合阿尔茨海默氏症病原和治疗方法的差距

Guo Chunhui^1,2, You Yanqiu², Chen Jibing³

¹Graduate School, Guangxi University of Chinese Medicine, Nanning, 530000, China.

Metabolic brain disease

|January 4, 2025

概括

阿尔茨海默病涉及血管损伤和神经退行. 非编码RNAs (ncRNAs) 调节这些过程,外体可以将它们用于潜在的中枢神经系统疾病治疗.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
生物化学生物化学

背景情况:

阿尔茨海默病 (AD) 是老年人痴呆的主要原因,与神经退行症和废物清理受损有关.
血管假设认为,早期的血管损伤有助于AD的发病,包括粉样蛋白斑块和Tau的积累.
非编码RNAs (ncRNAs),如长非编码RNAs (lncRNAs),microRNAs (miRNAs) 和圆形RNAs (circRNAs),都与AD调节有关.

研究的目的:

审查阿尔茨海默病的多因素性质.
探索ncRNAs在AD病变发生中的调节作用.
讨论对于AD治疗的ncRNAs外体介导输送的潜力.

主要方法:

关于阿尔茨海默病,ncRNAs和外体的研究的文献综述.
分析涉及ncRNAs作为竞争性内源RNAs的复杂调节网络.
检查细胞间ncRNA跨血脑屏障传输中的外体功能.

主要成果:

ncRNAs参与调节AD的多种致病机制.
lncRNAs和circRNAs可以作为竞争的内源RNAs,抑制miRNAs并形成调节网络.
外基因组可以在细胞之间转移ncRNA,可能会穿越血脑屏障,并提供一种非免疫性药物递送策略.

结论:

阿尔茨海默氏症是一种复杂的神经系统疾病,具有多因素的起源.
ncRNAs为了解和准多个AD病原性途径提供了一个有希望的途径.
基于外体的ncRNAs传递为AD等中枢神经系统疾病提供了潜在的治疗策略.

关键词:

AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD ADD was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was 阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这就是CeRNA.循环RNA 是一个循环RNA.异构体是什么? 异构体是什么? 外构体是什么?这是一个LncRNARNA.这就是米RNA.

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