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Updated: Jun 4, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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生物有效性协议:使用转录组和蛋白质组分析在轴性脊柱关节炎患者中确定TNF抑制剂有效性的生物标志物

Rita Pinheiro Torres1, Ana Filipa Fernandes2, Sara Maia3

  • 1ULS Cova da Beira.

ARP rheumatology
|January 4, 2025
PubMed
概括

这项研究旨在发现使用Adalimumab的轴性脊柱关节炎 (axSpA) 患者治疗成功的早期指标. 它将分析基因和蛋白质的变化,以改善类风湿病的精密医学.

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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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