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在土耳其,Streptococcus pyogenes的抗微生物耐药性和流行病学模式

Nihan Ünübol¹, Nese Caglayan², Sinan Cebeci²

¹Department of Medical Microbiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey; Medical Laboratory Technician Program, Vocational School of Health Services, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Journal of infection and public health

|January 4, 2025

概括

耐药性A组链球菌 (S. pyogenes) 感染是一个全球性问题. 在土耳其,特定菌株 (emm类型1,12,89) 引发流行病,表现出对宏类的耐药性,但不表现出对青素的耐药性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
流行病学流行病学

背景情况:

A组β-溶血性链球菌 (S. pyogenes) 是重要的全球性病原体.
在S. pyogenes中耐药性需要持续监测.

研究的目的:

确定在土耳其引起感染的流行S. pyogenes菌株.
评估这些菌株对抗生素的敏感性,特别是对β-乳酸盐和宏类的敏感性.
分析S. pyogenes分离的克隆传播和流行病学相关性.

主要方法:

使用青素梯度测试来确定最小抑制度 (MIC).
通过脉冲场凝电泳术 (PFGE) 进行emm类型和DNA指纹识别.
从土耳其医院中分离的92种S. pyogenes菌株的分析 (2020-2022年).

主要成果:

确定了导致土耳其感染的主要S. pyogenes菌株.
在一些菌株中观察到抗红素耐药性;没有检测到对青素的耐药性.
该研究将emm类型和PFGE与追踪S. pyogenes流行病学的相关性.

结论:

1,12和89型被确定为导致土耳其流行病感染的主要S. pyogenes基因型.
PFGE基因型定型和emm型定型是S. pyogenes流行病学中的基因组分类的有效工具.
了解菌株流行病学和耐药性模式对于公共卫生管理至关重要.

关键词:

这是一种β-lactam.药物耐药性药物耐药性药物耐药性一组A型链球菌麦克罗里德,PFGE,emm类型的编写

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