怀孕期间蒸汽和围产期结果之间的关联:系统性审查和元分析
Andy Deprato1, Arundhati Garud2, Danila Azzolina3
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada; Alberta Respiratory Centre, Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Journal of hazardous materials
|January 4, 2025
概括
产前电子烟显著增加了对母亲和新生儿不良后果的风险. 这一系统性审查强调了怀孕期间的电子烟作为一个危险因素,敦促人们提高意识和监管,以保护母亲和婴儿的健康.
科学领域:
- 围产期健康 围产期健康
- 生殖毒理学 生殖毒理学
- 公共卫生 公共卫生
背景情况:
- 越来越多的担忧将产前电子烟与不良周围产生的结果联系起来.
- 缺乏一个批判性的,系统的评估,比较吸烟与不吸烟的孕妇.
- 了解这些关联对于孕产妇和新生儿健康政策至关重要.
研究的目的:
- 系统地评估和批判性地比较与产前vaping暴露相关的产周结局.
- 进行现有研究的元分析,以量化怀孕期间电子烟的风险.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Scopus,科学网,科克兰图书馆,PROSPERO,谷歌学者) 进行系统的文献搜索,直到2024年7月5日.
- 包括23项研究,包括924,376名参与者,其中7552人报告了独家产前电子烟.
- 对母亲和新生儿的结果进行了逆变量随机效应元分析.
主要成果:
- 产前蒸汽与53%更高的母亲不良结果的几率有关 (OR: 1.53).
- 具体的母亲风险包括母乳养减少 (OR:0.53) 和不充分的产前护理 (OR:0.69).
- 产前蒸汽还显示新生儿不良后果的几率增加了53% (OR: 1.53),包括低出生体重 (OR: 1.56),早产 (OR: 1.49) 和对于妊娠年龄来说小 (OR: 1.48).
结论:
- 这一全面的元分析确定了产前电子烟是造成母亲和新生儿不良后果的重要危险因素.
- 调查结果强调,迫切需要提高有关怀孕期间电子烟的认识和监管措施.
- 电子烟的潜在危害扩展到人类健康和环境福祉.
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