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血栓构成对虚拟血栓切除术程序的影响,使用人体凝块类似物机械数据数据

Virginia Fregona¹, Giulia Luraghi², Behrooz Fereidoonnezhad³

¹Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Italy.

Journal of the mechanical behavior of biomedical materials

|January 4, 2025

概括

这项研究使用计算模型和凝块类型来研究急性缺血性中风的内血管血栓切除术 (EVT). 研究结果显示,红细胞含量显著影响了EVT期间的凝块碎片化和检索困难.

科学领域:

生物医学工程生物医学工程
计算流体动力学的流体动力学.
神经学神经学

背景情况:

血管内血栓切除术 (EVT) 对于通过移除脑动脉阻塞来治疗急性缺血性中风至关重要.
在EVT期间的血栓碎片化可能会使凝块检索复杂化,并影响程序的成功.
了解血栓力学对于优化EVT设备和策略至关重要.

研究的目的:

为了评估EVT模拟的验证数值方法的适用性,考虑到血栓碎片化.
为了研究血栓组成对in silico EVT结果的影响.
为了提高准确性,将人类凝块模拟实验数据集成到计算模型中.

主要方法:

对不同成分 (红细胞含量) 的人体凝块类似物进行实验测试.
材料模型的校准,结合基于实验数据的故障标准.
使用校准模型进行EVT的in silico模拟,将三种血栓组合与三种支架检索器设计相结合.

主要成果:

实验测试显示了压力-张力不对称性和降低度,红细胞含量更高.
模拟表明,故障标准的依赖性取决于血栓网格大小.
富含红细胞的血栓显示出更大的分裂倾向,而缺乏红细胞的血栓则增加了检索难度.

结论:

血栓的组成显著影响在内血管血栓切除术期间的碎片化和检索.
用实验性凝块模拟数据验证的计算建模,为EVT机制提供了宝贵的见解.
这些发现可以为改进的支架取回器和急性缺血性中风的干预策略的开发提供信息.

关键词:

急性缺血性中风是一次急性缺血性中风.医疗保健中的数字双胞胎有限元素分析的研究.在形医学中.进行血栓切除术 (thrombectomy).

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