![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
在CAR-T细胞治疗中出现的风湿性并发症. 一个单一中心的经验
José A Gómez-Puerta1, Ana Monegal1, Andrés Ponce2
1Department of Rheumatology, Hospital Clínic; University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Seminars in arthritis and rheumatism
|January 4, 2025
概括
化学抗原受体T细胞 (CAR-T) 治疗可能会导致罕见的类风湿并发症,包括类风湿性关节炎类症状和骨髓缩,在治疗后几周出现. 早期意识对于及时诊断和管理这些免疫相关事件至关重要.
科学领域:
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 化学抗原受体T细胞 (CAR-T) 治疗是一种新的血液恶性瘤治疗方法.
- 免疫相关的并发症,特别是风湿性表现,在CAR-T疗法接受者中尚未完全理解.
研究的目的:
- 调查CAR-T治疗后风湿并发症的发生率和特征.
- 提高与CAR-T治疗相关的潜在风湿性不良事件的临床意识.
主要方法:
- 对310名接受CAR-T治疗的患者进行了回顾性分析.
- 对诊断,症状发作,临床表现和风湿并发症治疗的患者数据的审查.
主要成果:
- 六名患者 (1.9%) 发生了类风湿并发症,包括类风湿性关节炎的表现,肌肉炎和骨硬化.
- 治疗后2至11周出现症状,表现不同,如炎症性关节炎,结节症和严重关节干扰.
- 活检和成像证实了诊断;治疗涉及葡萄糖皮质类药物,氧化和NSAIDs,有效性各不相同.
结论:
- 风湿并发症是CAR-T疗法的潜在,尽管不常见的不良事件.
- 对于接受CAR-T治疗的患者来说,迅速识别和管理是必不可少的.
- 需要进一步的研究,以了解这些自身免疫现象的机制和标准化治疗方案.
相关概念视频
01:29Autoimmune Disorders
2.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
01:24Tissue Transplantation
1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
01:23Rheumatic Heart Disease I: Introduction
1.0K
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K