在晚期癌症患者中,精准医疗的生存时间更长
C K Mapendano1, A K Nøhr2, M Sønderkær3
1Department of Oncology and Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
ESMO open
|January 4, 2025
概括
在大多数末期癌症患者中,分子分析确定了可操作的目标. 向治疗显著改善了接受这些治疗的人的整体存活率 (OS),突出了精确瘤学的好处.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 精准医学是一门精准的医学.
背景情况:
- 末期癌症患者往往缺乏有效的治疗选择.
- 分子瘤委员会 (NMTB) 评估针对性治疗的复杂病例.
- 在耐火性癌症中,评估针对性治疗的整体存活率 (OS) 是至关重要的.
研究的目的:
- 评估向癌症治疗的整体生存 (OS) 结果.
- 在末期癌症中,比较针对性治疗和无针对性治疗之间的结果.
- 分析分子分析在指导癌症治疗中的可行性和影响.
主要方法:
- 未来将患者纳入一个单一的瘤中心.
- 整体外体和RNA测序用于分子分析.
- 在国家分子瘤委员会 (NMTB) 提交病例,以提出治疗建议.
主要成果:
- 在大多数患者中发现了驱动器变异;42%的患者有多个受影响的途径.
- 42%的人发现了可行的目标,但只有三分之一的人接受了推的治疗.
- 目标治疗的中位数是15个月,而没有目标治疗的5-6个月,显著差异 (P=0.004).
- 多变量分析确定了向治疗,更少的转移部位和腺癌组织学作为OS的积极预测因素.
结论:
- 对于末期癌症患者来说,组织不可知的向治疗越来越可行.
- 分子分析和向治疗提供了显著的生存益处.
- 尽管确定了可使用药物的目标,但治疗开始仍存在挑战.
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