对心理压力的唾液皮质醇反应降低预测了一般人群中所有原因的死亡率
Han Yin1, Zihan Gao1, Mengyang Jia1
1The Second Clinical Medical College, Jinan University, Shenzhen 518020, China; Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.
Journal of psychosomatic research
|January 4, 2025
概括
对压力的唾液皮质醇反应减弱与更高的全因死亡风险有关. 高度炎症,特别是IL-6,显著介导这种增加的死亡风险,表明干预目标.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 下垂体-垂体-上腺 (HPA) 轴调节压力反应,唾液皮质醇作为关键生物标志物.
- 皮质醇对压力的反应性降低与不良健康结果有关.
- 了解皮质醇反应,死亡率和调解因素之间的联系对于公共卫生至关重要.
研究的目的:
- 调查精神压力下降的唾液皮质醇反应和全因死亡率之间的关联.
- 识别和量化可修改因素的作用,如炎症和运动,在调解这种关系.
- 探索预防性干预的潜在目标.
主要方法:
- 利用了MIDUS II研究的数据,随访时间为16年 (n=1129).
- 根据唾液皮质醇对精神压力的反应对参与者进行分类 (响应者与非响应者).
- 采用LASSO-物流,考克斯回归和受限制的立方线分析,包括治疗权重的反向概率进行调整.
主要成果:
- 皮质醇反应减弱的个体表现出更高的抑郁症状,增加IL-6水平,以及更低的定期炼率.
- 升高的IL-6和缺乏定期运动被确定为显著的可修改因素.
- 皮质醇反应降低与全因死亡率增加有关 (HR=1.33),其中13%的风险是由IL-6升高的介导.
结论:
- 对压力的唾液皮质醇反应减少是所有原因死亡率的重要预测因素.
- 升高的IL-6水平在这种关联中起着关键的调解作用.
- 研究结果强调了针对炎症和生活方式因素的干预措施的潜力,以减轻死亡风险.
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