瘤微环境介导的第二次近红外光激活多功能级联纳米酶用于自我补充O2/H2O2多式瘤治疗
Yu Chen1, Haiqiong Cao1, Chaoqun Jiang1
1School of Physics and Electronic Sciences, Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering, Changsha University of Science and Technology, Changsha 410114, PR China.
Journal of colloid and interface science
|January 4, 2025
概括
这项研究引入了一种新的级联纳米酶,该纳米酶针对瘤微环境 (TME),以增强癌症治疗. 该纳米酶结合了饥饿,化学动力学,光热和免疫疗法,以改善治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 开发适应瘤微环境 (TME) 的纳米酶对于有效地在现场治疗癌症至关重要.
- 在癌症治疗中设计连锁策略以获得高治疗效率仍然是一个重大挑战.
研究的目的:
- 开发一种多功能级联纳米酶 (Cu2-xO@MnO2@GOx@HA),对结直肠TME有反应,用于组合疗法.
- 研究纳米酶在饥饿疗法,化学动力疗法 (CDT),光热疗法 (PTT) 和免疫疗法的潜力.
主要方法:
- 一个Cu2-xO@MnO2@GOx@HA纳米酶的制造.
- 利用TME特定的触发物 (酸度,H2S) 来顺序激活治疗功能.
- 使用近红外II (NIR-II) 光用于深层组织PTT.
- 利用葡萄糖氧化酶 (GOx) 来自供应H2O2以增强CDT并诱导饥饿疗法.
主要成果:
- 在酸性TME中的MnO2分解产生O2,缓解缺氧.
- 2-xO的化为2-xS使NIR-II触发的PTT成为可能.
- Cu2-xS为CDT产生基基 (OH),由GOx产生的H2O2.2增强.
- GOx还通过摄入葡萄糖来诱导饥饿疗法.
- 生成的ROS触发免疫细胞死亡 (ICD),激活抗瘤适应性免疫力.
- 氨酸 (HA) 涂层可以提高瘤向和整体治疗效率.
结论:
- 开发的TME响应级联纳米酶有效地集成了PTT,CDT,饥饿疗法和免疫疗法.
- 这种多功能纳米酶在协同作用,瘤特异性癌症治疗方面具有显著的潜力.
- 这些发现为设计先进的TME响应纳米酶为增强癌症治疗铺平了道路.
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