使用GCMS和LCMS/MS进行三种Sargassum多囊提取物的不偏见的代谢和化学分析:内容分析,相关性分析和分子对接分析
Batoul Alallam1, Hassan Taiye Abdulameed2, Vuanghao Lim1
1Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam 13200 Kepala Batas, Penang, Malaysia.
Food chemistry
|January 4, 2025
概括
马来西亚棕色海藻 Sargassum polycystum提取物分析了健康益处. 乙醇提取物显示出优越的抗氧化和抗癌特性,表明食品工业的潜力.
科学领域:
- 海洋生物学 海洋生物学
- 物理学的生理学
- 食品科学 食品科学 食品科学
背景情况:
- Sargassum polycystum是一种棕色的大藻类,富含植物化学物质.
- 其潜在的健康益处,包括抗氧化和细胞毒性质,在马来西亚人群中尚未得到充分探索.
- 了解提取物成分是解开其生物活性的关键.
研究的目的:
- 为了表征马来西亚S. polycystum提取物的植物化学物质和生物活性.
- 为了研究化学成分和健康益处之间的相关性.
- 为了确定对抗氧化和抗癌作用负责的潜在生物活性化合物.
主要方法:
- 使用水和乙醇进行提取.
- 植物化学分析 (蛋白质,含量).
- 抗氧化活性测定 (DPPH激素清理).
- 对MCF7乳腺癌细胞的细胞毒性测定.
- 没有针对性的代谢分析.
- 相关性和分子对接分析.
主要成果:
- 水提取物具有高蛋白质和含量,但抗氧化和抗癌活性较低.
- 乙醇提取物表现出显著的抗氧化活性 (IC50 = 397.90 μg/mL) 和对MCF7细胞的选择性细胞毒性 (IC50 = 338.63 μg/mL).
- 代谢分析显示了提取物中不同的化学特征,与观察到的生物活性相关.
结论:
- 马来西亚S. polycystum的乙醇提取物具有强大的抗氧化和抗癌特性.
- 乙醇提取物中的特定生物活性化合物需要进一步研究食品工业应用.
- 这项研究强调了提取方法在确定S. polycystum的生物活性方面的重要性.
关键词:
抗氧化剂是一种抗氧化剂.化学测量方法 化学测量方法提取物 提取物代谢学 代谢学 代谢学多变量数据分析多变量数据分析.萨尔加索姆多囊 (Sargassum polycystum) 是一种多囊的生物.更多相关视频
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