胆酸通过调节LPS挑战肉肠道微生物群的组成来缓解肠道炎症
Guoqiang Fan1, Wenjing Chen1, Jianxing He1
1Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing 210095, PR China.
Research in veterinary science
|January 4, 2025
概括
食胆酸 (BAs) 和石灰酸 (LCA) 补充剂可以预防 brojlers 的肠道炎症. 这些化合物改善肠道健康,调节微生物群,并减少受挑战的鸟类的炎症反应.
科学领域:
- 动物科学动物科学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 胆汁酸 (BAs) 被认为是家禽有益的料补充剂.
- 关于使用BA来预防肉肠道炎症的研究有限.
- 脂聚糖化物 (LPS) 挑战是诱导 brojlers 肠道炎症的常见模式.
研究的目的:
- 为了研究饮食BA和石灰酸 (LCA) 对肉中LPS诱导的肠炎的影响.
- 评估BA和LCA对肠道形态,炎症标志物和胆酸代谢的影响.
- 分析BA和LCA补充后肠道微生物群组成的变化.
主要方法:
- 180个Arbor Acres肉被分为四个组:对照组,LPS挑战组,BAs+LPS组和LCA+LPS组.
- 用BAs化合物或LCA进行食补充剂.
- 使用LPS挑战来诱导肠道炎症.
- 测量包括肝脏质量,血AST,炎症性细胞因子,肠道形态,胆酸代谢和16SrRNA基因测序用于肠道微生物群分析.
主要成果:
- 随着LPS挑战,肝脏质量显著增加,血AST和炎症性细胞因子显著增加.
- 补充BA化合物或LCA可以改善肠道损伤,减少炎症,改善胆酸代谢.
- 补充BA或LCA抵消了LPS诱导的细菌多样性的减少,并增加了诸如Bacteroides和Bifidobacterium之类的有益细菌.
- 增加Candidatus_Arthromitus的丰度与肠道炎症性细胞因子水平负相关.
结论:
- 食胆酸化合物和石灰酸显示在缓解肉LPS诱导的肠道炎症方面具有潜力.
- 补充BA和LCA可以积极调节肠道微生物群组成,改善肠道健康.
- 这些发现表明BA和LCA是有前途的料添加剂,可以预防家禽的肠道炎症.
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