肠道微生物群通过 lncRNA Snhg9 保护大肠直肠瘤发生
Meng Wang1, Kailin Liu1, Wu Bao1
1Zhejiang Provincial Key Laboratory of Pancreatic Disease of The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, Zhejiang, China.
Developmental cell
|January 4, 2025
概括
肠道微生物群通过抑制称为Snhg9.9的长非编码RNA (lncRNA) 来保护大肠直肠癌 (CRC). 消耗肠道细菌增加Snhg9,加速CRC的进展.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 结肠直肠癌 (CRC) 的发展受到肠道微生物群的影响.
- 肠道微生物组在CRC病变发生中的作用,特别是在炎症的背景下,需要进一步阐明.
研究的目的:
- 研究肠道微生物群对结直肠瘤发生的保护作用.
- 确定微生物群对CRC发育产生影响的分子机制.
主要方法:
- 使用大肠炎症和CRC的小鼠模型.
- 使用抗生素治疗来耗尽肠道微生物群.
- 分析长非编码RNASnhg9的表达和功能及其与p53,SIRT1和CCAR2.2的相互作用.
主要成果:
- 肠道微生物群在患有轻度结肠炎症的小鼠中保护CRC.
- 微生物的存在抑制了lncRNA Snhg9的表达,这通常促进瘤生长.
- Snhg9通过破坏SIRT1-CCAR2复合体来抑制瘤抑制剂p53,从而促进细胞循环的进展和抑制细胞亡.
- 抗生素诱导的微生物群枯竭导致Snhg9上调和加速CRC进展.
- 人类SNHG9与小鼠Snhg9共享功能性保护,通过相同的分子途径促进瘤生长.
结论:
- 肠道微生物群在CRC发育中起着保护作用,特别是在炎症条件下.
- 微生物抑制Snhg9是这种保护的关键机制.
- 针对Snhg9-p53-SIRT1-CCAR2轴是CRC的一个潜在的治疗策略.
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