在怀孕期间使用抗精神病药物以及孕妇和新生儿的结果

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Updated: Jun 4, 2025

19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

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Hanseul Cho¹, Hyesu Jo², Yi Deun Jeong¹

¹Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

Journal of affective disorders

|January 4, 2025

概括

奎平是一种常见的怀孕抗精神病药物,但其他一些如齐普拉西和帕利佩里可能是更安全的替代品. 需要进一步的研究来确认在怀孕期间使用抗精神病药物的安全性.

科学领域:

药物监督药物监督药物监督
生殖健康生殖健康
精神病治疗药物精神病治疗药物

背景情况:

怀孕期间抗精神病药物的使用正在增加,但个体安全性数据有限.
奎胺具有相对广泛的安全概况,使其成为比较的基准.
缺乏对怀孕期间抗精神病药物安全性的全面全球评估.

研究的目的:

在怀孕期间评估各种抗精神病药物的安全性.
为了比较haloperidol,ziprasidone,clozapine,olanzapine,risperidone,aripiprazole和paliperidone与quetiapine的安全性概况.
确定怀孕期间抗精神病治疗的潜在更安全的替代方案.

主要方法:

利用了世界卫生组织的药物监测数据库 (1968-2023).
分析了11406份关于怀孕期间接触抗精神病药物的报告.
对妊娠,胎儿和新生儿不良结果进行了不成比例性分析 (ROR).

主要成果:

哈洛佩里多尔显示,与奎平相比,先天性形的报告频率更高 (ROR 3.83).
所有研究的抗精神病药物对妊娠糖尿病的报告频率都低于奎平 (ROR 0.22).
帕利佩里和齐普拉西的重大不良结果报告频率与奎平相比相似或更低.

结论:

数据的局限性和报告偏差阻止了最终的因果关系.
与奎平相比,齐普拉西和帕利佩里在怀孕期间可能代表更安全的抗精神病替代品.
进一步的研究对于验证这些抗精神病药物在怀孕期间的安全性至关重要.

关键词:

抗精神病药物抗精神病药物全球全球全球全球全球全球怀孕怀孕怀孕怀孕世界卫生组织世界卫生组织

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