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马来西亚疫情幸存者在25年后仍然保留可检测的尼帕抗体和记忆B细胞

Hui Ming Ong¹, Puteri Ainaa S Ibrahim¹, Chee Ning Chong¹

¹Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

The Journal of infection

|January 4, 2025

概括

尼帕病毒 (NiV) 幸存者在感染后25年表现出持久的免疫记忆,对NiV-F和NiV-G糖蛋白具有可检测的抗体. 这表明NiV疫苗开发的潜力,以及改善疫情防治的准备.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
流行病学流行病学

背景情况:

尼帕病毒 (NiV) 构成了严重的公共卫生威胁.
了解长期免疫反应对于管理NiV感染和开发有效的对策至关重要.

研究的目的:

评估感染后25年幸存者对尼帕病毒 (NiV) 的长期幽默免疫反应.
为了确定可靠的血清学标记,过去的NiV暴露.

主要方法:

分析了1998年爆发的25名NiV幸存者的血清样本.
与酶相关的免疫吸收试验 (ELISA) 用于检测针对NiV核体 (N),融合 (F) 和附着 (G) 糖蛋白的IgG抗体.
还评估了中和抗体标位和B细胞记忆反应.

主要成果:

针对NiV-F (56%) 和NiV-G (60%) 的抗体被检测到大多数幸存者在1:100稀释时,具有比抗NiV-N抗体 (20%) 更高的特异性.
所有阳性抗NiV-F和抗NiV-G样本都显示出中和活性.
活病毒中和试验证实,在72%的幸存者中可检测到中和抗体,这表明长期免疫力.
特定于NiV-F和NiV-G的B细胞记忆反应在幸存者的小组中被确定.

结论:

尼维融合 (F) 和附着 (G) 糖蛋白是确定过去尼维暴露的有希望的生物标志物.
这些发现支持在NiV感染后存在持久的免疫记忆.
持续监测和研究对于NiV疫苗开发和未来疫情准备至关重要.

关键词:

艾丽莎·伊丽莎·伊丽莎在IgG IgG的基础上.记忆B细胞是记忆中的B细胞.中和抗体的抗体.尼帕病毒是尼帕病毒.

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