含有氨基功能化CoFe2O4纳米颗粒的离子交联复合凝作为生物活性和pH响应药物递送系统
Ujwala Guntakanti1, Sreekanth Reddy Obireddy1, Madhavi Chintha2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapur 515003, India.
International journal of biological macromolecules
|January 4, 2025
概括
这项研究开发了使用酸,甲基纤维素和功能化铁纳米颗粒的新型复合凝,用于控制药物输送. 这些pH响应的凝在制药应用中显示出作为生物活性载体的潜力.
科学领域:
- 软物质物理学 软物质物理学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 复合凝为各种应用提供可调节的性能.
- 现有的纯凝缺乏用于先进的生物医学用途的灵活性.
研究的目的:
- 创建和描述用于控制药物释放的新型复合凝.
- 研究这些凝作为生物活性载体的潜力.
主要方法:
- 将三乙烯四胺 (TETA) 功能化的铁酸盐纳米粒子 (ANPs) 纳入藻酸盐 (SA) 和甲基纤维素 (MC) 水凝中.
- 结构性,热性和形态性质的表征.
- 评估胀,降解,药物释放和ROS产生能力.
主要成果:
- 确认ANP的成功整合.
- 复合凝表现出对pH的反应性和增强的稳定性.
- 证明了受控的药物释放概况和ROS产生能力.
结论:
- 开发的复合凝显示出作为先进的生物活性载体的前景.
- 这些材料需要进一步研究药物应用.
- 可调节的特性使其在癌症治疗和组织工程中具有潜在的用途.
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