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揭示了pullulan在增强PHBV纤维的烯释放中的潜力

Layde T de Carvalho¹, Maryana B da Silva², Thiago A Vieira²

¹Chemical Engineering Department, Engineering School of Lorena, University of São Paulo, Lorena, São Paulo, Brazil; IMT Mines Albi, RAPSODEE UMR CNRS 5302, Albi, France.

International journal of biological macromolecules

|January 4, 2025

概括

可持续的聚3-基酸-co-3-基酸) (PHBV) 和pullulan (PUL) 纤维丝与氨酸被开发用于骨再生支架. 普卢兰增强了烯释放和改善了支架特性,显示了生物相容性.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
组织工程是组织工程.

背景情况:

聚3-基酸-co-3-基酸 (PHBV) 是一种生物降解的聚合物,具有骨再生的潜力.
从脚手架上控制药物释放对于有效的治疗治疗至关重要.
普鲁兰 (PUL) 是一种天然的多糖,可以改变聚合物的特性.

研究的目的:

为了研究pullulan对PHBV含有烯酸的纤维的特性的影响,用于脚手架应用.
评估PUL/PHBV混合物的热,形态和生物行为.
为了评估基托从发育的细丝中的体外释放动力学.

主要方法:

制备的聚3-基酸-co-3-基酸) (PHBV) 和普鲁兰 (PUL) /PHBV的纤维丝,其中包括基.
使用汉森参数,差分扫描热量计 (DSC) 和扫描电子显微镜 (SEM) 的表征.
在骨质细胞的体外细胞毒性测试和烯溶解研究.

主要成果:

汉森参数表明混合物中聚合物和药物的可变性发生变化,导致热稳定和结晶性降低.
SEM图像显示,烯光滑和均化了灯丝表面.
细胞毒性测试证实了所有样本的生物相容性. 普鲁兰在240分钟内从0.1%增加到36%的累积烯释放量.

结论:

聚烯/PHBV混合物表现出可调节的热和形态特性.
开发的纤维是生物相容的,适合用于骨再生支架.
普鲁兰在控制甲释放动力学方面发挥着关键作用,为改善治疗结果提供了潜在的潜力.

关键词:

有控制释放的释放.凯托普罗芬是一种酸盐.在 PHBV 找 PHBV 聚合物混合物的混合物.普卢卢兰 (Pullulan) 是一个古老的语言.

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