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Updated: Jun 4, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

通过使用以omics为中心的方法,了解per-/polyfluoroalkyl物质的毒理机制

Xinyi Zhou¹, Fanglin Hu², Yafang Chen¹

¹College of Energy Environment and Safety Engineering, China Jiliang University, Hangzhou, Zhejiang, 310016, China.

Environmental pollution (Barking, Essex : 1987)

|January 4, 2025

概括

和多基基物质 (PFAS) 构成环境风险. 欧米克技术揭示了PFAS毒性机制,包括对新陈代谢和细胞通路的影响,突显了需要进一步研究的需要.

科学领域:

环境毒理学环境毒理学
分子生物学分子生物学
生物化学生物化学

背景情况:

和多醇基物质 (PFAS) 是广泛存在的环境污染物,具有已知的不良影响.
工业转向新兴的PFAS需要更深入地了解它们的分子毒性.
传统的毒理学方法在全面分析PFAS影响时是有限的.

研究的目的:

审查基于omics的洞察力,了解传统和新兴PFAS的有毒机制.
专注于关键的毒理终点:肝毒性,发育性,免疫性,生殖性和神经毒性,以及内分泌干扰.
突出多组学方法在PFAS毒理学的有用性.

主要方法:

关于PFAS暴露的omics研究 (转录组学,蛋白组学,代谢组学/脂组学,微生物组学) 的综合文献综述.
专注于过去五年内发表的研究.
在各种毒性类型中分析分子反应.

主要成果:

通过破坏脂质和氨基酸代谢,细胞信号通路和核受体结合,PFAS诱导毒性.
多omics方法提供了对PFAS毒性机制的整体理解.
肠道微生物群显著影响PFAS诱导的肝毒性.

结论:

奥米克技术,特别是多奥米克,对于阐明PFAS毒性机制至关重要.
了解PFAS对新陈代谢,信号和微生物群的影响是风险评估的关键.
未来的研究应该利用omics进行全面的PFAS毒理学研究.

关键词:

代谢学代谢学代谢学多个omics的多个omics.通过/多醇基物质.蛋白质组学是指蛋白质组学.有毒机制有毒机制.文字转录学 (Transcriptomics) 是一个学科.

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