与代谢功能障碍相关的稳态性肝病增加了原发性开角玻璃眼的风险
Chao Chen1, Jiao Qi1, Keke Zhang1
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China.
Ophthalmology. Glaucoma
|January 4, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与初级开角玻璃眼 (POAG) 的更高风险有关. 这种关联可能是因果关系的,突出显示肝脏.
科学领域:
- 眼科和肝病学 眼科和肝病学
- 研究肝病与肝外并发症之间的联系,特别是眼科疾病,如初级开角玻璃眼 (POAG).
背景情况:
- 肝病包括各种疾病,包括与代谢功能障碍相关的脂肪性肝病 (MASLD),酒精性肝病 (ALD),病毒性肝炎和肝硬化.
- 眼科疾病,如初级开角绿内障 (POAG),越来越多地被认为是肝病的肝外并发症.
- 关于主要肝病与POAG.之间存在的特定关联的证据有限.
研究的目的:
- 调查主要肝脏疾病 (MASLD,ALD,病毒性肝炎,肝纤维化和肝硬化) 与患初级开角玻璃眼 (POAG) 的风险之间的联系.
- 使用孟德尔随机化 (MR) 分析探索潜在的因果关系.
主要方法:
- 使用英国生物库队列 (n=332,345) 进行的前性研究,采用双样本孟德尔随机化 (MR) 分析.
- 严重的肝病 (MASLD,ALD,病毒性肝炎,肝纤维化,肝硬化) 通过住院被定义,并使用Cox比例危险模型分析为时间变化的暴露.
- 用MASLD (n=19,264) 和POAG (n=216,257) 的全基因组关联研究数据进行了MR分析.
主要成果:
- 严重的MASLD与发生POAG的风险增加45%相关 (HR,1.45;95%CI,1.12-1.87).
- 在ALD,病毒性肝炎或肝纤维化/肝硬化和POAG风险之间没有发现显著的关联.
- 门德尔随机分析提供了证据,支持MASLD与POAG风险增加之间的因果关系 (OR,1.035;95%CI,1.010-1.061).
结论:
- 严重的MASLD与发生POAG的风险增加长度相关,有证据表明存在潜在的因果关系.
- 这些发现强调了在MASLD的综合管理中考虑POAG查的重要性.
- 这项研究强调了肝脏健康对眼睛健康的重大影响.
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