非洲胆结石疾病的流行:系统性审查和元分析
Seid Mohammed Abdu1, Ebrahim Msaye Assefa2
1Biomedical Sciences, Wollo University, Dessie, Ethiopia seidmd041@gmail.com.
BMJ open gastroenterology
|January 4, 2025
概括
胆结石病影响着17%的非洲人口,女性患病率明显高. 由于数据的局限性和目前关于胆结石患病率的研究中的异质性,需要进一步研究.
科学领域:
- 胃肠病学和肝病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 胆结石病 (胆结石病) 是一个重要的全球健康问题.
- 非洲胆结石病的流行病学景观还不清楚.
- 了解患病率对于有针对性的公共卫生干预至关重要.
研究的目的:
- 系统地审查和综合现有关于非洲人口中胆结石疾病流行率的数据.
- 为提供非洲胆结石病的综合流行率估计.
- 为了识别人口结构模式,如性别特异性流行.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 从2000年到2023年12月,搜索了主要的数据库 (PubMed,谷歌学者,Hinari,非洲杂志在线).
- 包括报告胆结石患病率的观察性研究;使用随机效应模型提取和分析的数据.
主要成果:
- 十项观察性研究符合纳入标准,导致胆结石病的综合流行率为17% (95% CI 9%24%).
- 在研究中观察到很高的统计异质性 (I2=99.9%).
- 在报告性别特异性数据的研究子集中,女性 (15.3%) 与男性 (3.7%) 相比,患病率显著更高.
结论:
- 在非洲,胆结石病的综合流行率估计为17%,明显女性占主导地位.
- 显著的异质性,来自许多非洲国家的有限数据和多样化的研究人群需要谨慎的解释.
- 未来的公共卫生战略应优先考虑减少胆结石病,特别是在女性中,同时解决数据差距和变异性.
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