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外分胰腺功能的血清标记在区分发展为1型糖尿病的个体方面具有差异性的信息性
MacKenzie D Williams1, Catherine Ramsey Grace1, Amanda L Posgai1
1Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA.
BMJ open diabetes research & care
|January 4, 2025
概括
外分胰腺酶如脂酶和素原,以及遗传风险得分和自身抗体,有助于区分1型糖尿病 (T1D) 状态. 这些生物标志物显示出预测T1D进展的前景.
科学领域:
- 内分泌学和新陈代谢学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 血清中生长激素,阿迪波金和分泌胰腺酶的水平变化与1型糖尿病 (T1D) 个别相关.
- 岛屿自身抗体 (AAb) 和遗传风险评分 (GRS) 是T1D的已知因素.
- 需要对这些多样化的生物标志物进行全面的评估,以预测T1D的预测效用.
研究的目的:
- 为了集体评估七个血清生物标志物 (IGF1,IGF2,阿迪波涅克丁,莱普丁,胺酶,脂酶,试原),以及岛屿自身抗体 (AAb) 和遗传风险评分 (GRS2).
- 确定这些标记物在预测自身抗体和1型糖尿病状态方面的有用性.
- 根据血清学和遗传特征,区分T1D的不同阶段和糖尿病前期状态.
主要方法:
- 分析了来自543名参与者 (2.7-30.0岁) 的横截面血清样本,包括T1D患者,一个或多个岛屿自身抗体 (1AAb+,≥2AAb+) 的个体,以及自身抗体阴性对照 (AAb-).
- 测量包括IGF1,IGF2,阿迪波涅克丁,莱普,粉酶,脂酶和试原.
- 使用随机森林建模来评估这些生物标志物,AAb状态和GRS2.2的预测能力.
主要成果:
- 遗传风险评分 (GRS2),年龄,脂酶,素和特定自身抗体 (ZnT8,GAD65,胰岛素) 是最有信息的标志物.
- 与AAb-对照组相比,较高的GRS2和较低的脂酶水平与≥2AAb+组有关.
- 降低素和增加的脂酶水平区分了最近出现的T1D与≥2AAb+组.
结论:
- 脂酶和试素水平是用于区分与1型糖尿病相关的临床群体的信息性血清学标志物.
- 这些异位胰腺酶的预测效用取决于GRS2和特定的自身抗体状态.
- 外分胰腺酶是1型糖尿病研究中纵向研究的有希望的候选者.
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