急性缺血性中风患者内血管治疗的氧化目标 (Oxy-TARGET):单中心,开放标签随机对照试验的协议
Zhengfang Hu1, Kangda Zhang1, Youxuan Wu1
1Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.
BMJ open
|January 4, 2025
概括
这项随机对照试验调查了急性缺血性中风的内血管治疗期间的最佳氧气水平. 这些发现将指导呼吸系统管理,以改善患者的治疗结果.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 麻醉学 麻醉学
背景情况:
- 临床前数据表明,氧气治疗对接受内血管治疗 (EVT) 的急性缺血性中风 (AIS) 患者有好处.
- 在全身麻醉下在EVT期间吸入氧气 (FiO2) 的最佳分数仍未确定.
- Oxy-TARGET试验通过比较高度与低度的氧气来解决这一知识差距.
研究的目的:
- 评估高度氧与低度诺莫巴里克氧对AIS患者EVT后早期神经功能的影响.
- 为了确定在全身麻醉下进行EVT的患者的最佳FiO2.
- 评估EVT期间与氧气管理相关的安全性和有效性参数.
主要方法:
- 具有平行设计的前性,开放标签的随机对照试验 (RCT).
- 招募200名在全身麻醉下接受EVT的AIS患者.
- 随机分配到FiO2=80%或FiO2=30%,记录了交付的FiO2.2.
主要成果:
- 主要结局:早期神经改善的发生率 (在EVT后24±2小时NIHSS得分<10).
- 二次结局包括24小时的DNIHSS,心脏病发作量,90天的mRS,神经系统恶化,肺部并发症,血液气体参数和死亡率.
- 数据收集正在进行中,结果正在等待.
结论:
- 该研究旨在提供基于证据的建议,用于在AIS的EVT期间进行氧气管理.
- 这些发现将增强麻醉师对这种患者群体呼吸支的理解.
- 结果将通过出版物和会议传播.
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