系统性免疫炎症指数和抑郁症在患有心血管疾病和没有心血管疾病的人群之间的关系
Dan Liu1, Chaojie He2, Xinguo Luo3
1Department of Clinical Psychology, The First Hospital of Jiaxing University, Jiaxing, 314000, China.
Journal of cardiothoracic surgery
|January 4, 2025
概括
系统性免疫炎症指数 (SII) 与抑郁症状的风险更高有关,特别是在没有心血管疾病 (CVD) 的人群中. 这表明SII可能有助于预测一般人群中的抑郁风险.
科学领域:
- 心血管医学 心血管医学
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 抑郁症经常与心血管疾病 (CVD) 一起发生,这两种疾病都与慢性炎症有关.
- 系统性免疫炎症指数 (SII) 是系统性炎症的标志物,但其与心血管疾病患者抑郁症状的相关性尚不清楚.
研究的目的:
- 调查SII与心血管疾病患者和没有心血管疾病患者的抑郁症状之间的关联.
- 为了确定SII是否可以作为抑郁症状的预测因素.
主要方法:
- 利用了来自2005-2016年国家健康和营养检查调查 (NHANES) 的29,479名参与者的横截面数据.
- 使用患者健康问卷 (PHQ-9) 评估抑郁症状.
- 计算SII (血小板计数 × 中性粒细胞计数/淋巴细胞计数) 并使用逻辑回归和平滑曲线拟合分析相关性.
主要成果:
- 在总人口中,较高的SII与抑郁症状的增加显著相关 (OR:1.101).
- 与患有心血管疾病的人相比,没有心血管疾病的人 (OR: 1.121) 的相关性更强 (OR: 1.055).
- 最高SII第三位的参与者表现出明显更高的抑郁症状风险,特别是在非心血管疾病组 (OR: 1.161).
结论:
- SII独立地与抑郁症状的风险增加有关,尤其是在没有心血管疾病的个体中.
- 在一般人群中,SII可能是抑郁症状的有价值预测因素,有助于早期查和干预.
- 需要进行进一步的研究,以了解SII的潜在机制和临床实用性,以评估抑郁症状,特别是有关心血管健康的症状.
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