糖尿病相关牙周炎的免疫病原和免疫治疗
Shuangshuang Li1,2, Shuang Li1,3, Lingxiao Meng1,3
1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China.
Clinical oral investigations
|January 4, 2025
概括
糖尿病相关牙周炎 (DPD) 涉及免疫失衡. 免疫疗法通过准这种免疫失调来为DPD提供有前途的治疗方法,从而有可能改善患者的治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病严重影响牙周健康,导致糖尿病相关牙周炎 (DPD).
- DPD的免疫病原发生涉及高血糖,下微生物群和宿主免疫反应之间的复杂相互作用.
- 了解这些免疫机制对于开发有效的治疗策略至关重要.
研究的目的:
- 审查糖尿病相关牙周炎 (DPD) 的免疫病原发生.
- 探索针对DPD的免疫治疗药物的研究进展.
- 确定新型治疗方法的潜在临床应用.
主要方法:
- 在主要的科学数据库 (PubMed,MEDLINE,Embase,Web of Science,Scopus,Cochrane Library) 中进行了全面的文献搜索.
- 纳入标准侧重于将糖尿病与牙周炎联系在一起的研究,没有时间或语言限制.
- 搜索术语包括糖尿病,牙周炎,免疫病原生,免疫力和免疫疗法.
主要成果:
- 高血糖症会改变下菌群,引发免疫过度活跃或抑制和细胞防御功能受损.
- 表观遗传因素和女性荷尔蒙也会导致DPD的发展.
- 临床证据支持甲二醇,多西环素,米诺环素和甲胺;临床前研究显示,维生素D3和其他药物具有前景.
结论:
- DPD的特点是免疫失衡,突出显示了免疫治疗药物的潜力.
- 将免疫疗法与非手术性牙周治疗结合起来,为DPD管理提供了新的治疗途径.
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