:全球临床试验的48年的旅程
Yikun Wu1,2, Jun Pei3, Yuangao Xu4
1Guizhou University Medical College, Guizhou University, Guiyang, 550025, China.
Molecular and cellular biochemistry
|January 4, 2025
概括
本综述总结了48年的临床试验,重点是美国.
科学领域:
- 微量矿物质的研究.
- 临床试验分析临床试验分析
- 营养科学 营养科学
背景情况:
- 是一种必不可少的微量矿物质,近五十年来越来越多的临床试验调查.
- 美国一直是开发试验研究集群和合作的核心.
研究的目的:
- 为 1976 年至 2023 年期间进行的临床试验提供全面的概述.
- 分析研究的演变,趋势和未来方向.
主要方法:
- 从1976年到2023年对临床试验数据的系统审查和分析.
- 观察和干预试验的分类.
- 确定关键的功能分类和来源.
主要成果:
- 的临床试验经历了不同的阶段:出现,繁荣和过渡.
- 观察性试验经常发现低水平,而干预试验则专注于抗氧化剂,内分泌和代谢疾病.
- 无机和半有机形式是主要的,纳米出现;口服是标准的,每天200μg的上限.
结论:
- 未来的研究应该专注于功能机制,由参与代谢,炎症和免疫的基因指导.
- 临床试验应优先考虑具有更高疗效的疾病,例如涉及抗氧化剂和内分泌/代谢功能的疾病.
- 本综述提供了关于在健康和疾病中的作用的见解,并确定了未来研究的途径.
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