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Updated: May 7, 2025

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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通过分子伴侣来调节生理和病理凝聚物

Nadeen Akaree1, Valentina Secco2, Flonia Levy-Adam1

  • 1Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

The FEBS journal
|January 5, 2025
PubMed
概括

压力颗粒 (SGs) 和其他生物分子凝聚物在细胞压力和像ALS/FTD这样的疾病中起作用. 异常的SG可能会播种病理性蛋白质聚合物,伴侣会调节生理和病理凝聚物,以进行潜在的疾病干预.

关键词:
这就是ALS.这是一个FTD.这就是FUS FUS.这就是LLPS.在TDP-43中.聚合方式 聚合方式 聚合方式陪伴者 (chaperones) 是指一个陪伴者.凝结剂是一种凝结剂.蛋白质稳定症是一种蛋白质稳定症.压力颗粒是压力颗粒.

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