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腹部PP网格涂有功能核心盖可生物降解的纳米纤维,具有抗凝和抗菌特性

Malo Dufay¹, Maude Jimenez¹, Mathilde Casetta¹

¹Univ. Lille, CNRS, INRAE, Centrale Lille, UMR 8207 - UMET - Unité Matériaux et Transformations, F-59000 Lille, France.

Biomaterials advances

|January 5, 2025

概括

使用生物活性聚合物开发了功能性网涂层,以防止术后并发症. 这些新型材料具有抗凝固和抗菌特性,减少粘附和感染等风险,改善患者的治疗结果.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
手术创新在外科创新.

背景情况:

腹修复经常使用织网,但附着和感染等并发症发生在一半以上的病例中.
这些与网状组织相关的并发症可能导致慢性疼痛,并需要切除植入物,突出需要改进的生物材料.
目前降低风险的策略包括在网格表面上增加物理障碍.

研究的目的:

开发具有双重抗凝和抗菌活性的功能性网.
使用生物活性聚合物为网状涂层制造核心盖纳米纤维.
评估这些功能化的网格在预防术后并发症方面的有效性.

主要方法:

合成一种聚硫酸 (多2-烯-2-甲基硫酸,PAMPS) 具有抗凝活性和一种含有三元胺的聚合物 (多2-三-丁胺) 乙烯基甲酸盐,PTBAEMA) 具有抗菌活性.
聚乙烯 (PCL) 芯的同轴电与生物活性聚合物外,以创建纳米纤维.
优化电参数,以在网上提供无缺陷,水稳定的纳米纤维涂层.

主要成果:

成功地制造出具有PCL核心和生物活性聚合物 (PAMPS或PTBAEMA) 覆盖的核心覆盖纳米纤维.
优化的电产生了稳定的,无缺陷的纳米纤维涂层在网上.
实验室研究证实了功能化的网格的细胞相容性,显著的抗凝剂活性和强大的抗菌特性.

结论:

开发的功能性网涂层显示了预防术后粘附和感染的巨大潜力.
双作用涂层提供了一个有前途的策略,以减少在修复中与网状网相关的并发症.
这项创新可以显著改善患者的康复,并减少在手术后需要进行植入物切除的需要.

关键词:

腹部的治疗腹部的治疗具有抗菌活性,具有抗菌活性.抗凝剂活性抗凝剂活性同轴电旋转的电旋转方式.手术后的附着物.

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