在中年和老年人口中,水质和神经退行性疾病风险
Yujia Bao1, Yongxuan Li1, Yanqiu Zhou1
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ecotoxicology and environmental safety
|January 5, 2025
概括
较低的水硬度 (0-120 mg/L) 可能会增加患阿尔茨海默病和血管痴呆的风险. 这项研究强调需要更新水质指南,以保护大脑健康并支持可持续发展目标.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 可持续的水资源管理对发展至关重要,但与水硬度相关的长期健康风险尚未得到充分研究.
- 评估水硬度的系统风险需要进一步调查其神经影响.
研究的目的:
- 为了估计不同水硬度水平对大脑系统的影响.
- 完善与神经退行性疾病有关的水硬度的系统风险评估.
- 为更新的水质指南提供证据,并支持可持续发展目标.
主要方法:
- 从英国生物银行收集了397265名参与者的大量队列.
- 使用统计建模来调查水硬度与神经退行性疾病之间的关联.
- 分析了脑成像表型,包括特定区域的脑缩,与水硬度相关.
主要成果:
- 0-120毫克/升的水硬度水平与120-300毫克/升的水硬度水平相比,与阿尔茨海默病 (HR 1.13) 和血管痴呆症 (HR 1.24) 的发病风险增加有关.
- 观察到较低的水硬度和部分大脑缩之间存在关联,特别是在尾状核和下叶.
- 这些发现表明,水硬度和神经健康风险之间存在剂量依赖的关系.
结论:
- 低水硬度与主要神经退行性疾病的风险增加有关.
- 特定的大脑区域显示与水硬度水平相关的缩.
- 该研究强调,需要制定精确的水硬度准则,以保护公众的大脑健康,并为可持续发展做出贡献.
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