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Updated: Jun 25, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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新型FGFR1 PROTACs的设计,合成和生物评估

Yu-Wei Wang1, Yu-Hui Gao1, Cheng Wang1

  • 1Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, PR China.

Bioorganic chemistry
|January 5, 2025
PubMed
概括

研究人员开发了S2h化合物,这是一种新型的蛋白质溶解向嵌合体 (PROTAC),可以有效降解癌细胞中的纤维细胞生长因子受体1 (FGFR1). 这一发现为克服癌症治疗中对FGFR抑制剂的耐药性提供了一种新的策略.

关键词:
它具有抗瘤活性.E3 无处不在酸接酶一个FGFR1.降解FGFR1的降解剂在PROTAC分子中.

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