酵母可以缓解二酸诱导的氧化应激和丸损伤
Ningna Xiong1, Sili Liu1, Wei Hu2
1College of Life Science and Resources and Environment, Yichun University, Yichun, Jiangxi 336000, China.
Animal reproduction science
|January 5, 2025
概括
酵母 (SeY) 保护的丸免受二 (DQ) 诱导的氧化应激. SeY增强了抗氧化防御,减少了亡,并支持精子生成和合成,保护雄性家禽的生殖健康.
科学领域:
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
- 营养生物化学 营养生物化学
背景情况:
- 迪奎特 (DQ) 是一种亲氧化农药,诱导氧化应激,特别有害于家禽在生长和繁殖期间.
- 酵母 (SeY) 是一种有机来源,具有高效率和低毒性,以其抗氧化特性而闻名.
研究的目的:
- 评估酵母 (SeY) 对子丸中迪卡特 (DQ) 诱导的氧化应激的保护作用.
- 调查SeY对精子生成,合成,氧化应激标志物,细胞亡和细胞增殖对DQ暴露的的影响.
主要方法:
- 在DQ暴露之前,公已经接受了SeY的预处理.
- 评估精子生成,精子生成细胞数和合成基因的表达 (StAR,P450scc,3β-HSD).
- 测量了抗氧化酶活性 (CAT,T-SOD),甲酸 (MDA) 水平,以及与亡相关的基因/蛋白质表达 (Bax,Bcl-2,Caspase3,NF-κB),以及增殖标记Ki67.
主要成果:
- SeY预处理减轻了DQ诱导的丸损伤,改善了精子生成和细胞丰富性.
- SeY激活了Nrf2/HO-1通路,提高了抗氧化酶的活性,并减少了MDA.
- 通过调节相关的基因/蛋白质表达和通过Ki67表达增强精子细胞增殖来减弱SeY的亡.
结论:
- 酵母有效地保护的丸免受迪卡特诱导的氧化损伤.
- 通过减少氧化应激,抑制亡,促进增殖和增强合成基因表达,SeY具有保护作用.
- 这项研究为使用SeY来保护雄性家禽的生殖健康免受农药暴露提供了理论基础.
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