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Updated: May 7, 2025

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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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全球心血管协作网络 (GLOB-cAGE) 是由心血管疾病的老年人组成的全球心血管协作网络
Jie Jun Wong1, Gary Tse2, Huyen Thi Thanh Vu3,4
1Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore.
American journal of epidemiology
|January 5, 2025
概括
全球心血管衰老研究联盟 (GLOB-cAGE) 团结了患有心血管疾病的老年人的全球队列. 该倡议协调了先进元回归分析的数据,改善了研究代表性,并解决了证据差距.
科学领域:
- 老年学是一门学科.
- 心血管流行病学心血管流行病学
- 全球健康 全球健康
背景情况:
- 全球心血管衰老研究联盟 (GLOB-cAGE) 是一个新的国际倡议.
- 它将世界各地的老年人与心血管疾病 (CVD) 的纵向队列结合在一起.
- 旨在协调对老年人群中心血管疾病的元回归分析数据.
研究的目的:
- 建立一个全球数据库,用于老年人心血管研究.
- 使用标准化主体级数据进行元回归分析.
- 加强全球多元人口在衰老和心血管疾病研究中的代表性.
主要方法:
- 涉及基于人口的纵向队列研究和临床试验.
- 包括被诊断患有心血管疾病的个人和那些面临初级预防风险的人.
- 要求最低样本大小为100名参与者 (年龄>65岁或>40岁,长期随访).
主要成果:
- 目前包括来自9个国家的27项研究,共有10个参与团队.
- 通过共享数据 (匿名或原始数据) 促进协作.
- 为无法共享数据的网站提供替代参与方法.
结论:
- GLOB-cAGE解决了因临床试验中老年人代表性不足而导致的证据差距.
- 促进对老年人口心血管健康的高质量流行病学研究.
- 加强老年心血管研究的全球合作和数据标准化.
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