早期青春期前症后的精神分裂症:一种神经发育亚型,具有自闭症类感官运动和社会认知缺陷
Anton Iftimovici1,2,3, Gilles Martinez1,2, Julie Victor3
1Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team "Pathophysiology of psychiatric disorders", Institut de psychiatrie, CNRS GDR 3557, 75014 Paris, France.
精神分裂症 (SCZ) 早期前兆显示社会认知缺陷和感觉运动障碍类似于自闭症谱系障碍 (ASD). 这些与神经发育轨迹相关的障碍表明,前兆发作是SCZ分组的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 精神分裂症 (SCZ) 发作通常是由精神病定义的,但前兆症状通常出现在童年或青春期.
- 这项研究调查了SCZ与早期青春期前症候群 (SCZ-eaP) 与自闭症谱系障碍 (ASD) 的特征相比,SCZ与青春期后期前症候群 (SCZ-laP) 的特征是否相同.
研究的目的:
- 为了比较社会认知和神经软标志 (NSS) 在ASD,SCZ-eaP,SCZ-laP和对照.
- 探索NSS和社会认知之间的关系,以及它们的神经发育的基础.
主要方法:
- 在四个组 (ASD,SCZ-eaP,SCZ-laP,对照组) 的119名参与者中,使用电影任务评估了社会认知和NSS.
- 分析包括年龄,性别,智商,教育和药物.
- 用调解分析和局部化指数来检查神经发育联系.
主要成果:
- 患有ASD和SCZ-eaP的个体表现出类似的社会认知和NSS,与SCZ-laP不同.
- 较早的前发症发作与更严重的NSS和较差的社会认知相关.
- NSS调解了跨群体的社会认知缺陷,并与特定大脑区域的高化有关.
结论:
- 在SCZ中较早出现的先发症与受损的社会认知有关,由ASD-SCZ频谱特征的感觉运动障碍介导.
- 不仅仅是精神病发作,而且是前兆发作,对于定义同质的SCZ亚组至关重要.
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